For people who suffer from anaphylaxis, a severe allergic reaction that can result from an allergy to certain foods, latex, insect bites, insect stings, medications and even exercise, it is important to always carry two doses of epinephrine, a medication that is self-injected into the thigh that works to immediately help alleviate the potentially life-threatening symptoms of a severe allergic reaction prior to obtaining emergency medical care.

There are several brands of self-injectable epinephrine that a doctor can prescribe. The Twinject Auto-Injector is the only auto-injector that provides two doses of epinephrine in one device.

Following is an overview of important attributes of the Twinject device:

Indication / Approved Uses

The Twinject has been approved by the U.S. Food and Drug Administration (FDA) for the emergency treatment of Type-1 allergic reactions, which includes stinging insects (e.g., bees, wasps, hornets, yellow jackets, fire ants); biting insects (e.g., mosquitoes); foods (e.g., milk, egg, peanut, tree nuts, fish, shellfish, wheat, soy); diagnostic testing substances (e.g., radiocontrast media); and medications, as well as latex and exercise-induced anaphylaxis.


Each Twinject is capable of delivering two doses of epinephrine. The first dose is delivered as an automatic injection by the patient, while the second dose needs to given manually through a partial disassembly of the device by the patient.

Since the dose of epinephrine needed to treat an allergic reaction is dependent on the weight of the person, the Twinject is available in two dose strengths. The Twinject 0.15 mg contains enough epinephrine for people who weigh between 33 and 66 pounds. The Twinject 0.3 mg contains enough epinephrine for people who weigh more than 66 pounds.

Injection Site

The Twinject should only be injected into the upper thigh. It is important to not inject the Twinject device in the buttocks as it may not be effective in helping to reverse the allergic reaction.


It is important to keep either the Twinject nearby at all times for immediate use. The Twinject should be stored at room temperature and should not be exposed to extreme heat or cold temperatures. Remember to check the expiration date of the Twinject and replace it if it is not used by that date.

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